Introduction :
Hemophagocytic syndromes (HS) have experienced a very significant revival in recent years, there are considered as a rare pathology but a lot of progress has been made thanks to improved knowledge and the multiplication of publications and the establishment of well-coded protocol for treating this syndrome.
HS have poor diagnosis, it can be definded by overstimulation of the immune system leading to systemic inflammation, cytokine storm and multi-organ failure.1
They constitute a heterogeneous group and can be divided into two primary hemophagocyte categories lymphohistiocytosis (HLH) and secondary hemophagocytic syndromes.2
Herein we report a rare case of a woman with stage secondary HLH to Hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection, the first case in Morocco to our knowledge. The patient achieved complete remission with antiviral treatment and chemotherapy. Through this work we highlight the need of more research and collaboration across all physicians as well as sharing information about similarities and differences between cases, and about their management to improve the overall prognosis and to raise awareness about this malignancy among physicians and patients.