Chapter 10
Chromatin Biology
History and timeline:
1831: Discovery of nucleus
1871: Discovery of nucleic acid by Freidreich Mieschner
1882: For the first time, chromatin was visualized by Walther Flemming
1884: Discovery of histones ( A. Kossel)
1941: Consensus on histones are inheriting molecules at CSHL meeting
1944: Transforming bacteria with DNA by Avery and MacLeod
1953: Double helix DNA
1970-72: Superhelical models of chromatin. Histones are outside of the DNA.
Chromatin architecture
Chapter 21
Development of multicellular organisms