In the following abstract we describe DatasetDatabase (DSDB), an open-source system for handling the provenance, versioning, de-duplication, history, and query of dynamic databases used at the Allen Institute for Cell Science. We present our initial design and deployment of DSDB, the results of this work for computational modeling, and conclude with a discussion of the future work necessary for provisioning data discovery and sharing tools that facilitate transparent reproducible research through provenance aware features.