Table 1. The table summarizes some recent studies on restoring neurogenesis in aged murine, via regulation of BDNF and/or IGF-1. Ki67 and BrdU are proliferative markers of adult neurogenesis. DCX is an immature neuron marker that can be used to identify newborn neurons or neuroblast. Dendritic morphology was indicated by dendritic complexity, length and branching in the above studies. ‘↑’indicates a significant increase in the corresponding index and ‘-’indicates no significant differences are observed. ‘/’ refers to non-tested index in that particular research.