BDNF promotes hippocampal neurogenesis through specific binding and activation of its receptor, tropomyosin-related kinase receptor B (TrkB) [7]. It has been reported that increasing BDNF level improves dendritic complexity during hippocampal neurogenesis [8] and subserves neural circuit formation and brain computation [9]. However, the limited delivery, short half-life [10] and poor permeability trough brain-blood barrier (BBB) [11] of BDNF impede its therapeutic potential, resulting in disappointed performance of direct use of BDNF in clinical trials. Hence, people are looking for strategies to induce BDNF productionin vivoand for the past few decades, antidepressant treatment has been studied widely [12]. In recent years, more researches focus on alternatives to accelerate BDNF-induced neurogenesis.