Adult neurogenesis continuously produces new neurons for integration into the neural circuits throughout adulthood, which has been implicated in cognitive functions. Neurogenesis in the hippocampus is highly regulated by a number of regulators, including BDNF and IGF-1, and their decrease with age is responsible for the decline in neurogenesis. Accumulating studies suggest that age-related decrease in hippocampal neurogenesis could be restored through multiple interventions, covering small molecular drugs, natural compounds and physical exercise. In this review, I present a discussion of current findings to revitalise hippocampal neurogenesis via enhancing BDNF and IGF-1 effects in the brain.