BDNF binds with TrkB and accomplishes neurogenesis improvement via activation of downstream signaling pathways, mainly involves withthe phospholipase Cγ (PLCγ),phosphatidyl inositol-3 kinase (PI3K) and extracellular signal- regulated kinase (ERK) cascades [11, 12]. These pathways all eventually induce activation and phosphorylation of cAMP response element-binding protein (CREB), the transcription factor mediating expression of genes essential for survival and development of neurons during hippocampal neurogenesis [12]. For example, higher levels of ERK and CREB phosphorylation has been detected in aged mice treated with TEE feeding [19], which demonstrated the important role of ERK/CREB pathway in promoting neurogenesis and cognition.