The idea to rejuvenate old bodies became popular since the anti-aging effect was reported in heterochronic parabiosis, which is joining two animals of different ages. Aged mice sharing circulatory systems with young mice gained improvements in multiple tissue regeneration, including neurogenesis [4]. This suggested that neurogenesis could be promoted by endogenous factors exist or have higher concentration in the young organisms, compared to aged ones. Adult hippocampal neurogenesis is highly regulated by diverse neurotrophic growth factors, among which brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) are investigated most within the past two years [2,5]. The factors upregulate adult neurogenesis, stimulate neural stem cell differentiation, and subserve newborn neurons survival and maturation [5, 6]. Reductions in the expression levels of BDNF and IGF-1 have been observed during ageing and could account for the age-related hippocampal neurogenesis attenuation [5, 3]. Accordingly, BDNF and IGF-1 are potential targets in therapeutic applications to revitalise hippocampal neurogenesis in old age. Recent researches proposed multiple strategies to reverse age-associated cognition decline via increasing the effects of BDNF and IGF-1.