Neurogenesis is an endogenous process that involves neural stem cell (NSC) proliferation and differentiation, immature neurons survival and maturation as well as dendrite development [1]. In most mammals, adult neurogenesis occurs in the subventricular zone of the lateral ventricle and in the subgranular zone of the dentate gyrus in the hippocampus [1-2]. Although it has been verified that neurogenesis occurs throughout life [1, 2, 3], its progressive decline with age still causes problems of cognition impairment. In healthy ageing, many studies have confirmed that age-related deficits in learning and memory performance are associated with the reduction of hippocampal neurogenesis [3]. Hippocampus is vulnerable to detrimental effect of ageing and is always the first regions of brain to suffer injury. The decline in hippocampal neurogenesis is notably shown in reduced number of newborn neurons, decreased synaptic plasticity and poor dendrite morphology [2, 3], which together impair brain functioning in old age. In this regard, hippocampus has become one of the most important targets of attempts to alleviate aged-related brain damages.