In addition to small molecules, other studies are using natural compounds to restore hippocampal neurogenesis in healthy ageing. Tomato ethanolic extracts (TEE) has been previously reported as a natural neuroprotective agent that reverses neurogenesis impairments in Parkinson’s disease [17-19]. Recent work by Bae and colleagues further confirmed its cognitive-enhancing effect in healthy ageing. TEE treated aged-mice had shown reversal of memory impairment, increase in newborn neurons and synaptic plasticity. This restoration of hippocampal neurogenesis was attributed to enhancement of BDNF and reduction of corticosterone after oral TEE supplement to aged mice [19]. Corticosterone has been shown to down-regulate BDNF expression [20], suppress synaptic plasticity [21] and induce adult neurogenesis decline as well as cognitive impairment in rodents [22], which indicated that inhibition of corticosterone levels by TEE also involved in BDNF promotion and cognition restoration.