Tumor Location and Size (how was size/max dimension determined, confirm cm, what type of MRI t1 weighted, etc.)
Of the eleven tumors, GCTs were found exclusively as a part of the suprasellar or infundibular regions (4/4; Fig. 2), PCTs were found exclusively as a part of the infundibular or sellar regions (4/4), while SCOs were found in the suprasellar, infundibular, or sellar regions (3/3). GCTs were statistically significant (p < 0.05) to be absent from the sellar region and were the only masses to be found exclusively as a part of the infundibular region (2/11). Pre-operative MRI scans were used to determine tumor sizes in the vertical direction and maximum dimensions in the horizontal direction. The average tumor was 1.93 cm in size and 0.72 cm in max dimension, with GCTs averaging 1.48 cm in size and 0.63 cm in max dimension, PCTs averaging 2.23 cm in size and 0.79 cm in max dimension, SCOs averaging 2.13 cm in size and 0.61 cm in max dimension. Fig. 3 depicts the relative location, size and maximum dimensions of the eleven different tumors.
 
Operative Findings (what were specific endocrine abnormalities (hypothyroidism, hypotestosteronism, amenorrhea, [pan]hypopituitarism, etc.), why is 0 endo complications important in SCOs, why did we use certain surg approaches for certain tumors, should pre-operative endo abn go in clinical presentation rather than this subsection)
Six tumors presented with pre-operative endocrine abnormalities findings, such as hypopituitarism. Interestingly, all of the SCOs (3/3; Fig. 1) had presented with pre-operative endocrine abnormalities, while only half of the total GCTs (2/4) and PCTs (2/4) exhibited these abnormalities. Two major surgical approaches, transsphenoidal (endoscopic/microscopic) or sylvian, were taken to resect these tumors. The majority of the tumors were resected with the microscopic technique (8/11; Fig. 2), with the PCTs (4/4) and SCOs (3/3) undergoing an exclusively microscopic sphenoidal surgical approach and the sylvian approach used exclusively on GCTs (2/4) and not PCTs (0/4) nor SCOs (0/4). Intraoperative findings showed that most of the tumors had a soft consistency (7/11; Fig. 5), including all of the SCOs (3/3). These tumors presented in different colors, with a majority appearing gray (7/11), and the rest appearing purple (2/11), tan (1/11), or white (1/11). Regarding specific tumors, we found that the SCOs (3/3) were all gray. The extent of resection for each of these tumors was determined using post-operative MRI, which showed a 100% gross total resection. Furthermore, the mean follow-up for the eleven cases was 4.72 ± 3.65 years with none of the cases displaying signs of any recurrence. With respect to post-operative findings, four cases displayed visual improvements while six cases exhibited endocrine abnormalities.
 
Histochemistry (organization – should we add in more discussion in this section)
Results for our immunohistochemistry are summarized in Fig. 6. In our eleven tumor cases, we found conflicting results from what has been published in previous literature. Although the literature describes PCTs as generally positive for GFAP staining8, we found that three of the four cases tested for GFAP staining had all reacted negatively. Moreover, EMA staining showed mixed results in GCTs and PCTs, whereas all three SCOs cases reacted positively, both of which have also been shown in the literature9. When testing S100 reactivity, we found that all of the tumors tested (8/8) stained positively, which was shown to be positive in PCTs9,10, but showed both positive and negative results in SCOs9,10. A key finding was that all eleven of the masses, including the three SCO cases, had positive staining towards TTF-1. This is important to take note of especially since TTF-1 has been shown to be highly expressed in pituicytes6, corroborating a common pituicyte lineage in GCTs and PCTs6,11, while also inviting speculation about the specific characteristics of SCOs12.