The histopathological study revealed that the cause of death for the Dole Whip® Only was the rupturing of the spleen; hence no spleens were shown in the above figure. In addition, the mice in the DW Only group suffered from acidification of the blood due to high levels of formic acid within the bloodstream. The prevalence of formic acid is attributed to the high levels of methanol seen in the blood tests results of this group (Table 1) in which an enzyme known as alcohol dehydrogenase turns methanol (which is typically non-toxic) into formic acid (a toxic compound). The elevated levels of formic acid disrupt the equilibrium of the pH buffers within the bloodstream that keep the pH at a level that allows for cell processes to function properly. With the mice's bodies unable to undergo the necessary processes to survive, they were unable to survive. 
As for the organs themselves, typical sizes for a mouse's spleen and lymph nodes were reflected within the Control group, with the other two group's sizes being compared to it. In the DW+Regular group, both the spleen and lymph nodes are visibly swollen yet still maintain its general conformation in relation to the control group's spleen and lymph nodes. In the DW Only group, the lymph nodes are more than four times the size of the control group's lymph nodes and have a different appearance, no longer resembling a typical lymph node. Although it is possible that swelling may have occurred at some point with these lymph nodes as well, the lymph nodes from the DW Only group could not have reached this size without experiencing some type of induced cell growth. Based on prior research on the effects of aspartame consumption, this compound has been known to cause lymphoma [one of the aspartame studies]

     3.5 - IHC Analysis of Affected Organs