What is the main question the study attempts to answer?
The authors of this preprint set out to investigate the
structure-function relationship of the huntingtin (HTT) protein, in its
apo form, as it undergoes polyglutamine expansion, a mutation which
results in Huntington’s disease. This builds upon previous work by these
researchers (Vijayvargia et al 2016 eLIFE ) which
investigates polyglutamine tract-dependent modulation of HTT structure
and function.