Workflow of the DNA adductome analysis, including sample preparation (1), HRMS analysis and data processing (2), and an example of a statistical evaluation (3) performing permutational multivariate analysis of variance (PERMANOVA), similarity percentage analysis (SIMPER), orthogonal partial least squares discriminant analysis (OPLS-DA), and receiver operating characteristic (ROC) analysis to link specific adducts to the chemical exposure. Modified from \cite{Martella2023}.