OMICS-based ecosurveillance.  Current discussions center on integrating OMICS-based technologies (genomics, transcriptomics, proteomics, lipidomics, metabolomics, and adductomics) into ecosurveillance monitoring frameworks. This integration aims to capture the comprehensive biological responses of ecosystems under perturbation \cite{Beale2022,Bahamonde2016}. These technologies and the data they can provide have greatly enhanced our grasp of how environmental chemicals impact ecosystems and human health. However, despite progress, most environmental OMICS are currently in the data collection phase, with crucial gaps in linking toxicity data with OMICS endpoints \cite{Machuca-Sepúlveda2023a}. Future efforts are expected to address real environmental challenges, focusing on issues like chemical mixture toxicity, biomarker identification, and the development of innovative OMICS approaches towards more effective chemical toxicity testing, risk monitoring, and sustainable natural resource utilization \cite{Beale2022}.
DNA adductome - an exposome component.  Adductomics, an emerging research field, provides structural insights into chemical exposures and serves as a platform for discovering biomarkers to identify both the occurrence of exposure and associated effects. DNA adductomics, one of the newest OMICS techniques, is particularly well suited for assessing exposure and effects of environmental contaminants \cite{Lockridge2023} and elucidating genotoxic and epigenetic changes due to chemical stressors.  
DNA adducts are well-established biomarkers in (eco)toxicology. They are chemical modifications occurring when certain chemicals bind covalently to DNA molecules. Unrepaired DNA adducts can disrupt DNA structure and function, potentially leading to mutations and adverse biological effects \cite{Phillips_2009}. These adducts are associated with health issues, reproductive toxicity, genotoxicity, and epigenetic alterations in humans and wildlife. For the last 50 years, DNA adducts have been used as biomarkers of exposure in human health diagnostics and environmental toxicology, where the focus has mainly been on the adducts derived from polycyclic aromatic hydrocarbons (PAHs) in fish and mussels as exposure biomarkers \cite{Pampanin2017,Dolcetti2002}. In environmental toxicology, PAHs have been most commonly linked to DNA adduct formation \cite{Skarphédinsdóttir2007,Amat_2004,Meier2020}, both in the laboratory and in field observations after oil spills. However, other contaminants have also been found to induce DNA modifications \cite{Guilherme_2012,letters}. Also, in amphipods, abundant epigenetic DNA modifications have been associated with contaminated environments \cite{Martella2023} and females that carry embryos with various developmental disorders \cite{Gorokhova2020}. Thus, ample evidence supports the informative value of detecting and quantifying DNA adducts in biological samples for assessing contaminant exposure and genomic effects.