Environmental contaminants induce adverse effects across biological levels, necessitating precise assessment tools. DNA adducts, which are chemical modifications to DNA, provide crucial insights into genomic effects and find broad applications in environmental toxicology and related fields. Liquid chromatography coupled with mass spectrometry (LC-MS) and, lately, with high-resolution mass spectrometry (HRMS), has emerged as the forefront technique for detecting and quantifying DNA adducts. HRMS allows comprehensive screening of adducts from diverse exposure classes, yielding detailed insights into modification types, chemical structures, and exposure diagnostics. This approach surpasses the constraints of classical assays, providing a superior omics perspective for understanding the impacts of contaminants on DNA. This opinion paper delves into the cutting-edge field of environmental adductomics, highlighting the emerging role of DNA adductome analysis in effect-based methods for monitoring and environmental health assessment. Discussed are target and non-target approaches for adduct identification, monitoring support and regulatory utilization, and showcasing the recent experience in surveying pollution impacts on DNA adductomes in wildlife. We suggest that DNA adductomics is a technologically mature, mechanism-based novel approach ready for adoption in environmental research and monitoring to facilitate a comprehensive assessment of environmental impacts.