Abstract:
 In this Review, we discuss the pathogenesis of MDS/MPN, focusing on the relationship between genotype and phenotype and the molecular underpinnings of epigenetic dysregulation.  Starting with the limitations of current therapies, we also explore how the available mechanistic data may be harnessed to inform strategies to develop rational and more effective treatments, and which gaps in our knowledge need to be filled to translate biological understanding into clinical progress.
Introduction:
Biological instructions for a cell identity is encoded in its genetic makeup while epigenome controls how this information is further interpreted and utilized to form specialized cells. Any alterations in this genetic and epigenetic landscape are associated with the formation of malignant cells suggesting their potential role in tumorigenesis \citep{Scourzic_2015}. Focusing on the epigenomic alterations,  DNA methylation is markedly abnormal in tumors in contrast to the normal tissues where deviations from orderly patterns of DNA methylation can alter the expression of cancer-causing genes  . 
Cancer 
role of DNA meth in cancer
DNA methylation
5mc and 5hmc
Importance of 5mc and 5hmc in different cancer in general