4.2. Pharmacokinetics
Pharmacokinetics of terpene indole alkaloids includes intravenous injection and continuous infusion showing triphasic clearance from plasma. For all indole alkaloids, in alpha and beta phases, distribution is similar, involving uptake from peripheral tissues and formed blood elements (Emanuela et al., 2018). In the later phase, distribution differs among indole alkaloids depending upon drug release from different tissues. The mitotic agents are metabolized in the liver. The plasma half-life of various indole alkaloids is vincristine (23-85 h), vinblastine (20-64 h), vindesine (20-24 h), and vinorelbine (18-49 h). Furthermore, all terpene indole alkaloids follow the clearance route of biliary elimination through feces with negligible renal clearance (Nelson, 2010).