3.2.2 Investigation effect of type of magnetic metal-organic framework nanocomposite on curcumin uptake
First made a 10 mg/lit solution of curcumin and sampled 100 cc of it. Synthesized magnetic metal-organic frameworks HKUST-1 with different weight percentages and NiFe2O4@SiO2nanocomposites as adsorbents in a ratio of (2:1) and the drug added to 100 cc curcumin solution sample. Then it was placed on the shaker at room temperature. As in the previous step, sampling and absorption amounts were calculated.
Fig (6): Effect of different percentages of containing metal-organic framework nanocomposite and Nickel ferrite nanocomposite on the silica substrate on adsorption.
The results showed in Fig (6), the magnetic nanocomposite (NiFe2O4@SiO2) adsorbed 73% after 8 hours. This value was less than the adsorption of curcumin by metal-organic framework nanocomposite (NiFe2O4@SiO2@HKUST-1) and under the same conditions, metal-organic framework nanocomposite (NiFe2O4@SiO2@HKUST-1) absorbed 78.45% after 8 hours. After 8 hours, these particles were homogeneous in curcumin solution and could not be separated. Over a period of 8 hours, magnetic nanocomposite containing a metal-organic framework with a 30 %wt weight higher percentage showed the highest absorption value (94%). According to the obtained results, for further investigation, magnetic metal-organic framework nanocomposite with a weight percentage of 30% wt. were used as an optimum percentage.
As shown in Table 5, based on the obtained results and comparison with other metal-organic frameworks, it can be concluded that magnetic metal-organic framework nanocomposite (NiFe2O4@SiO2@HKUST-1), like other metallic organic frameworks, is a viable option for uptake and drug interaction of curcumin.
Table (5): Evaluation of curcumin adsorption capacity on various metal-organic framework nanocomposites