Recommending the SCD in pregnancy CPGs for use in practice
The second (overall) assessment, regarding the recommendation for using the CPG in practice, revealed a consensus agreement between the reviewers on recommending the use of two of the appraised CPGs without modification including the RCOG and NHLBI CPGs and the other two CPGs with modifications (NICE, RCOG).
Strengths and limitations of the included CPGs are summarized in Table 4 based on the consensus and comments of the CPG appraisers for each item of the AGREE II.
All of the included CPGs cited systematic reviews in their references list. The largest number of systematic review citation was observed in the RCOG CPG (N=6) among them five were Cochrane reviews (83%). Overall, the lines of management of pregnant women with SCD were similar in these CPGs as shown in Table 5.