Main findings
Combination of NT-proBNP and sFlt-1 MoM improves prediction of short-term delivery due to early-onset pre-eclampsia between those pregnancies with an sFlt-1/PlGF ratio above 38, compared to higher sFlt-1/PlGF ratio raw value cut-offs. We have built a prognostic prediction calculator that is freely available at http://sbpsoftware.com/peprogntool.
Repeated sFlt-1/PlGF ratio of 38 or below adequately rule out early-onset pre-eclampsia leading to delivery within one week.
When sFlt-1/PlGF ratio is above 38, the addition of NT-proBNP has proven superior to the use of sFlt-1/PlGF ratio as a single marker. Gestational age-adjusted PlGF predictive ability is suboptimal and inferior than gestational age-adjusted sFtl-1. Therefore, after selecting at risk pregnancies using an sFlt-1/PlGF ratio cut-off of 38, repeated determinations of sFlt-1/PlGF ratio and predictions based solely on this marker cannot be recommended.