Figure 5. ACh efficiency in AChRs with a binding site mutation.
Mutations were at α−δ and α−ε binding sites (Purohit, Bruhova, Gupta & Auerbach, 2014): αY93 (W,H,A,F, S), αW149 (F, Y, A), αY190 (F, W, A), αY198 (F,H,W,S,T,L,A), εP121 (L,Y,G). The only mutation that reduced efficiency significantly was αY190A.