Web resources
BLAST,https://blast.ncbi.nlm.nih.gov/
ClustalW,https://www.genome.jp/tools-bin/clustalw
SIFT,https://sift.bii.a-star.edu.sg/
Polyphen-2,http://genetics.bwh.harvard.edu/pph2/
HGMD,http://www.hgmd.cf.ac.uk/ac/index.php
dbSNP,https://www.ncbi.nlm.nih.gov/snp/
Acknowledgments We thank Yi Wu and Na Chen for help with the
three-dimensional reconstruction. This work was supported by grants from
the National Natural Science Foundation of China (NSFC #81570933),
National Science and Technology Major Project for Transgenic Organisms
(2016ZX08009-003), and Key International (Regional) Joint Research
Program of National Natural Science Foundation of China
(NSFC#81820108009).
Authors’ contributionsConceived and designed the experiments: HW, SMY, YW, and WWG. Performed
the experiments: TTL, LL, YZ, CX, CHL, and LHL. Data analysis: TTL, LL,
HTS, and FX. Manuscript preparation: TTL, LL, YW, and WWG.
Availability of data and material the data that support the
findings of this study are available from the corresponding author upon
reasonable request.
Conflicts of interest the authors have declared that no
conflict of interest exists.