Web resources
BLAST,https://blast.ncbi.nlm.nih.gov/
ClustalW,https://www.genome.jp/tools-bin/clustalw
SIFT,https://sift.bii.a-star.edu.sg/
Polyphen-2,http://genetics.bwh.harvard.edu/pph2/
HGMD,http://www.hgmd.cf.ac.uk/ac/index.php
dbSNP,https://www.ncbi.nlm.nih.gov/snp/
Acknowledgments We thank Yi Wu and Na Chen for help with the three-dimensional reconstruction. This work was supported by grants from the National Natural Science Foundation of China (NSFC #81570933), National Science and Technology Major Project for Transgenic Organisms (2016ZX08009-003), and Key International (Regional) Joint Research Program of National Natural Science Foundation of China (NSFC#81820108009).
Authors’ contributionsConceived and designed the experiments: HW, SMY, YW, and WWG. Performed the experiments: TTL, LL, YZ, CX, CHL, and LHL. Data analysis: TTL, LL, HTS, and FX. Manuscript preparation: TTL, LL, YW, and WWG.
Availability of data and material the data that support the findings of this study are available from the corresponding author upon reasonable request.
Conflicts of interest the authors have declared that no conflict of interest exists.