Conclusion
This meta-analysis reveals to date only two studies have been published in which women received a HPV vaccination in addition to LEEP treatment for CIN2+ and evaluated the efficacy of HPV vaccination to prevent recurrence. Both studies had relatively small sizes and have their limitations. Nonetheless, in both studies a significant reduction in the recurrence of CIN2+ was seen with vaccination as an independent risk factor. The combined result of the sub-analysis of pooled data from large community-based trials was in favor of vaccination.
In conclusion the current literature does not provide a definite answer to the question whether adjuvant prophylactic HPV vaccination in addition to regular treatment has an additional effect. An RCT is lacking on this subject that may provide a definite answer to this issue. The ongoing VACCIN-trial (Dutch trial register: NL 7938) is expected to provide this answer.