Supplemental Figure:
Supplemental Figure 1:The blood glucose and serum insulin changes in different group of mice.A: The blood glucose changes in different group of mice. B: The serum insulin in different group of mice. Results are presented as means ± SDMs. *P < .05, significantly different as indicated; # P < .05 significantly different from C57 group;
Supplemental Figure 2: The relative expression of AMPK/SP1/PGAM5 and mitochondrial fission related protein in kidney. Results are presented as means ± SDMs. *P < .05, significantly different as indicated; # P < .05 significantly different from C57 group;
Supplemental Figure 3: The CCK8 assay which was used to tested the proper concentration of Empa in vitro study. # P < .05 significantly different from 0 ug/ml.