Figure 8 YDZG inhibits NLRP3 inflammasome activation in lung
tissue. Mice were treated with LPS and YDZG as described in the
Materials and Methods section. IL-1β in BALF (A), serum (B) and lung
tissue (C) were determined using ELISA kits. (D) The expression of NLRP3
and caspase-1 p20 proteins was determined by Western blotting (n=5). (E)
Immunohistochemical staining for NLRP3 in the lung tissues of mice
challenged with LPS. Immunoreactivity is shown in brown (scale bar = 100
μm). Data are reported as mean ± SEM; n = 8; *P < 0.05
compared with the LPS alone group.