BACKGROUND AND PURPOSE
Acute lung injury (ALI) is a challenging clinical syndrome that
manifests as an acute inflammatory response. The NLRP3 inflammasome is
involved in the development of ALI. Yadanzigan (YDZG) is isolated fromBrucea javanica (Linn.) Merr (Simaroubaceae) (Yadanzi), an
anti-inflammatory herb widely used in traditional Chinese medicine.
However, the anti-inflammatory effect and mechanism of YDZG on ALI have
not been reported.