YDZG reduces LPS-induced infiltration of inflammatory cells and
cytokine levels.
LPS-treated mice had more leukocyte (Figure 7A) and neutrophil (Figure
7B) counts in blood than that of the control. However, LPS- and
YDZG-treated mice had significantly fewer leukocytes and neutrophils
than mice treated with LPS alone. Moreover, LPS-challenged animals
showed significantly greater MPO activity in lung tissue (a marker for
neutrophils) than the control. Meanwhile, YDZG pretreated-mice had less
MPO activity than those treated with LPS alone (Figure 7C). In the
LPS-induced ALI model, YDZG decreased the LPS-induced inflammatory
cytokines TNF-α (Figure 7D) and IL-6 (Figure 7E) in BALF. Similar
results were found in serum (Figures 7F- G) and lung tissue samples
(Figures 6H- I), respectively. Thus, YDZG reduced the infiltration of
inflammatory cells and cytokine levels to prevent ALI.