Figure 9 Working model for YDZG-based inhibition of NLRP3 inflammasome activation. Firstly, YDZG inhibits LPS-induced NF-κB activation and disrupts NF-κB nuclear translocation to inhibit NLRP3 expression. Secondly, YDZG promote Nrf2 translocation from the cytoplasm into the nucleus and inhibited ROS generation. Finally, YDZG enhances TRIM31 expression and promote formation of TRIM31-NLRP3 complexes.