YDZG ameliorates LPS-induced acute lung injury in mice.
A lethal dose of LPS was intratracheally injected into lung tissue of
mice with non-invasive assay, and their survival rate were recorded. In
the LPS treated group, all mice died within 96 h after LPS injection,
however, mice pretreated with YDZG (5 mg·kg-1) had a
significantly greater survival rate (Figure 6A). In addition, results of
respiratory mechanic analysis indicated that LPS increased lung
functional indexes like the resistance of lung (RL) and resistance of
expiration (Re), and decreased respiratory lung compliance (Cdyn), of
which the effects of RL (Figure 6B), Re (Figure 6C), and Cdyn (Figure
6D) were significantly were reversed by YDZG pretreatment. Furthermore
histological analysis indicated that LPS triggered the infiltration of
antibacterial cells, thickened the alveolar wall, and destroyed the
normal lung tissue structure; YDZG treated groups prevented LPS-induced
acute lung injury (Figure 6E).