KEY RESULTS
YDZG specifically inhibits NLRP3 inflammasome activation. In cultured macrophages, YDZG attenuated the NF-κB pathway and mitochondrial reactive oxygen species production and enhanced TRIM31 expression to inhibit NLRP3 inflammasome activation. YDZG also ameliorated LPS-induced acute lung injury in mice by inhibiting the expression of NLRP3.
CONCLUSIONS AND IMPLICATIONSThis study uncovers the underlying mechanism and the anti-inflammatory activity of YDZG in ALI, suggesting that NLRP3 inflammasome may be an effective target of the treatment with ALI.
Keywords: Yadanzigan; NLRP3 inflammasome; NF-κB; TRIM31; Acute lung injury