Figure 4. Evaluation of drug efficacy in concomitant administration of metabolic inhibitors. (A) Estimation results using the PK–PD model. The drug efficacies are expressed as ratios of cell density to the cell density of control. (B) Cell density ratio of A549 cells in the MO–MPS expressed as a ratio to the cell density of control experiment (n=3 or 6; mean ± S.D.). Asterisks indicate significant differences (* P < 0.05; *** P < 0.005).