Figure 3. Evaluation of the drug efficacy in the MO–MPS. (A)
Cell density ratio of A549. The cell densities are expressed as a ratio
of cell density to cell density of control (n=3 to 6; mean ± S.D.).
Asterisks indicate significant differences (* P < 0.05; *** P
< 0.005). (B) Cell density ratio as a function of AUC of
SN-38. The dark broken line indicates the result of the MO–MPS with the
bypass channel, whereas the light broken line shows the result of the
MO–MPS without the bypass channel. (C) Metabolic map of CPT-11 in
vivo . CPT-11 is metabolized to APC and NPC by CYP3A4. CPT-11 and NPC
are metabolized to SN-38 by CES2. SN-38 and SN-38G are reversibly
metabolized by UGT1A1 and β-Glu.