Figure 1. Physiologically-based multi-organ microphysiological
system (MO–MPS). (A) Schematic of the blood flow ratio in vivo .
After flowing into the lung, the blood is distributed to the organs by
the heart. The flow ratio of the liver to the lung and heart is 1:3.3.
(B) Schematic illustration of the MO–MPS. The MO–MPS consist of a
liver part, a lung cancer part, and a stirrer-based micropump. The
values inside the arrows are the flow rate ratios. (C) Flow velocity in
the MO–MPS as estimated by ANSYS 17.1. The graph shows flow velocity on
A–A cross section. (D) Photograph of the fabricated MO–MPS with the
enlarged view of the stirrer-based micropump as inset. (E) Conceptual
diagram of PK model on the MO–MPS. The change in drug concentration is
dependent on the flow rate and extraction ratios of organ models.