BALF cells
In responders, mean CD4/CD8 ratio decreased from 9.2 to 3.0 (p=0.008), while both non-responders disclosed an increase, individual data shown in Fig. 2a. Mean number of mast cells per 10 visual fields in x16 magnification decreased from 26.0 to 3.8 in responders (p=0.04) but increased in both non-responders, see Fig. 2b. The change in cell concentration, percentage and absolute numbers of macrophages, lymphocytes, eosinophils and basophils between base-line and follow-up disclosed individual differences but no significant changes were observed. Cell concentration and lymphocyte data are shown in Fig. 2c-e. In responders, the mean percentage of CD4+ T-cell expressing CD69 decreased from 86.0 to 80.2 (p=0.01), while no change was seen in the two non-responders, shown in Fig. 2f. No significant change was seen in percentage of CD8+ T-cells expressing CD69. Percentage of CD4+ T-cells expressing forkhead box protein 3 transcription factor (FoxP3) decreased in all patients except two responders, number 7 and 8 (p=0.07), see Fig. 2g. We did not find anything in clinical phenotype or BALF data differentiating these from the other patients. BALF data at follow-up did not correlate with time span between last infusion of infliximab and bronchoscopy. Detailed individual information on BALF data is given in Supplement 3a-c.