LPS stimulates TNF-α secretion by freshly extracted human
leukocytes
Three in vitro cell-interaction models (Figure 2) were employed
to study the effects of LPS on TNF-α secretion by WBCs alone, or in
combination with HUVECs or HUVECs and erythrocytes. In the presence of
WBCs, erythrocytes and HUVECs, LPS promoted TNF-α secretion in a
dose-dependent manner when it was added incrementally in the range
0.0-0.5 ng ml-1.