Univariate and multivariate analyses
In the univariate analysis, residual nodules ≥1 cm and PFI <6 m were significantly associated with a high risk of death and disease progression in Cohort 1 patients with advanced disease (Table 2) . Age ≥53 years was associated with a high risk of death due to cancer. In a multivariate-adjusted model, PFI <6 m was the strongest predictor of disease progression (HR 27.78, 95% CI 15.87–47.62) and death (HR 5.92, 95% CI 3.82–9.17). BEV throughout and optimal cytoreduction in the front-line setting were independent predictors of reduced cancer progression (HR 0.43, 95% CI 0.25–0.73, and HR 0.63, 95% CI 0.44–0.90, respectively). Although BEV throughout was a predictor of cancer death, its impact was influenced by confounders in the multivariate analysis.
By cox proportional analysis in Cohort 2 patients, those with PFI of ≥6 m after primary therapy had significantly lower risks of death (HR 0.22, 95% CI 0.10–0.50) and next progression (HR 0.17, 95% CI 0.08–0.39) than those with PFI <6 m.