Cohort 2 with relapsed or persistent disease
The survival curves stratified by PFI of 6 and 12 m are illustrated inFigure 2 . Patients with PFI ≥6 m after primary therapy had a significantly better OS and PFS than those with PFI <6 m (P < 0.001 and P < 0.001, respectively) (Figure 2A ). Patients with a longer PFI had more favourable survival. Patients with PFI ≥12 m had greater OS and PFS than those with PFI <6 m (P < 0.001 and P< 0.001, respectively) (Figure 2B) .