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The protective effect of oleuropein from alzheimer disease as a natural drug
  • Faik Gökalp
Faik Gökalp
Kirikkale University
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Abstract

Background and Purpose: Oleuropein is found in olive trees and in the leaves of olive trees. It may have an important role in the treatment and possible prevention of of Alzheimer’s disease. Applied Approach: The aim of this study is to determine the chemical properties of oleuropein and determine the reactivity of this substance as well as Oleuropein’s inhibition effect on AChE.BChE. Key Results: DFT (Density functional theory), HF (Hartree-Fock) and docking methods were used to measure the chemical properties of oleuropein. The structures of the compounds were fully optimized by using the above-mentioned methods and the results were evaluated. Oleuropein is an unstable molecule and is prone to degredation possibly due to it containing a phenolic structure. Conclusion and Implications:The results of the present study indicate that it may play an important role in the treatment of Alzheimer’s disease.