3.2 Active phase INS patients Th2 cells were over-activation and
the expression of associated factors were increased.
The number of Tregs from patients’ whole blood was quantified by flow
cytometry (Fig. 2). The proportion of peripheral Th2 cells in initial
atopic group (5.60±1.21 vs. 3.29±1.02,P<0.05) and the initial
non-atopic group (4.23±0.92 vs. 3.29±1.02,P<0.05) were
significantly increased than that of healthy subjects, there was no
significant difference between remission atopy group and remission
non-atopic group (3.60±0.85 vs. 3.33±0.95,P > 0.05
) ; Compared with the initial atopic group, the other groups were
significantly decreased; Compared with the initial non-atopic group, the
initial atopic group was significantly higher, the control and the
remission non-atopic group were significantly reduced, and there was no
significant difference in the remission atopic group (Fig. 2A, B). We
detected plasma levels of IL-4 and IL-13 by CBA (Fig. 2C, D) and found
that plasma IL-4 and IL-13 concentrations were significantly increased
in initial atopic group (IL-4: 66.66±43.85 vs. 23.29±13.91,P < 0.05; IL-13: 65.15±16.50 vs. 15.66±8.16,P < 0.05) and the initial non-atopic group (IL-4:
37.04±17.39 vs. 23.29±13.91, P < 0.05; IL-13:
33.15±14.09 vs. 15.66±8.16, P < 0.05), there was no
significant difference between remission atopy group and remission
non-atopic group (22.09±10.32 vs. 16.47±11.69, P >
0.05 ); Compared with the initial atopic group, the other groups were
significantly decreased; Compared with the initial non-atopic group, the
initial atopic group was significantly higher, the control and the
remission non-atopic group were significantly reduced, and there was no
significant difference in the remission atopic group.