Exploring The Potential Impact of Pharmaceutical Care Plan on High
Sensitivity C-reactive Protein hsCrp in Post-Acute Coronary Syndrome
Patients in Cardiac Rehabilitation Unit
Abstract
Objective: This study aimed to assess the impact of clinical pharmacist
services addition to cardiac rehabilitation program, on high sensitivity
C-reactive protein and echocardiographic parameters. Methods: The study
was a prospective; randomized, controlled study. A total of 40
post-acute coronary syndrome (ACS) patients participating in cardiac
rehabilitation program were randomly allocated to either the control
group (n = 20) or the clinical pharmacist-provided services group
(n = 20). High sensitivity C-reactive protein (hs-CRP) and
echocardiographic parameters (left ventricular end systolic volume
(LVESV), left ventricular end systolic volume (LVEDV) and ejection
fraction (EF%) were compared between both groups at baseline and after
3 months. Results: After three months of follow-up, the intervention
group showed a significant decrease in the percent change of hsCRP,
LVESV and LVEDV compared to the control group. However, there was no
statistical difference in the percent change of ejection fraction
between both groups. Conclusion: Addition of clinical pharmacist
services to cardiac rehabilitation program had resulted in marked
decrease in hs-CRP, LVESV and LVEDV. Understanding the impact of the
clinical pharmacist-provided services in post-ACS patients may encourage
clinical implementation of this model in cardiac rehabilitation
programs.