Compliance with Ethical Standards
Disclosure of potential conflicts of interest: All authors declare no conflicts of interest
Ethical approval:  “All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Faculty of pharmacy, Ain Shams university, Cairo, Egypt (49), Clinicaltrials.gov registration no. NCT02922140, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.”
Informed consent: “Informed consent was obtained from all individual participants included in the study.”