AMPHETAMINE-induced locomotor activity
The psychomotor effects of AMPH were tested in a grey plywood open field
of 50 x 50 x 50 cm, which was illuminated by ~ 20 Lux.
After 30 mins of habituation, rats were treated with 0.5 mg/kg
amphetamine (SERT+/+: n=12; SERT-/-:
n=12), 1 mg/kg amphetamine (SERT+/+: n=13;
SERT-/-: n=13) or vehicle (SERT+/+:
n=12; vehicle SERT-/-: n=12) according to a standard
Latin square design using the same animals with a break of 4 weeks
between the various treatments. Distance moved was recorder for 120 mins
(Fig 1a), and analyzed afterwards using the ANY-maze video tracking
system (version 4.82) from Stoelting.