VitD3 supplemetation in infancy is associated with reduced asthma exacerbations
To analyze the role of VitD3 supplementation during infancy on asthma exacerbations, we then analyzed the number of asthma exacerbations and asked if VitD3 supplementation during infancy would associate with less disease exacerbations. Here we found that asthmatic children without VitD3 supplementation had more episodes of asthma exacerbations(Fig 2a) that were associated with induced CRP (Fig 2b), a factor associated with increased airway hyperresponsiveness(Fig 2c) . In conclusion, increased asthma exacerbations associated with CRP in the absence of VitD3 supplementation, indicating a possible protective role of VitD3 during asthma exacerbations.