Vit D3 reduced lung CD4+PD1+ CD4+ T lymphocytes independently
from ST2 deficient cells
We next asked if, in this in vitro system ViTD3 would rescue T cells
from cell death by inhibiting PD1 a marker of T cell
exhaustion.26 In
addition, we wanted to better understand the role of ST2 in T cell
survival. Here we found that, in the same experimental conditions
depicted in Fig 7, CD4+PD1+ T cells were inhibited by VitD3 in the
presence of allergen challenge dependently from ST2 (Fig 6c) .
In summary, VitD3, has a suppressive role on CD4+PD1+ T cells involved
in T cell exhaustion in the airways in the absence of ST2.