Conclusion:
The limitation of this study is reflected in the fact that it is a longitudinal observational study and not a randomized trial. However, randomization will be difficult due to the shortage of cases. The lack of information about the long term effect on live born babies can be criticized. However, we can conclude with the following:
1) The procedure is very safe, simple and inexpensive.
2) The procedure is very critical in making the final diagnosis and facilitating counseling of the family.
3) Majority of these cases have a major malformation not compatible with life.
This information influences the mode of delivery and decreases the chance of operative delivery with serious consequences.