3.3 Acute exacerbation of symptoms is associated with further
impairment of NO/sGC signaling.
Evaluation of putative changes in aggregability and responses to SNP
between chronic and acute (pre-NAC treatment) phases was made via paired
analyses (n = 14; Fig. 2 ). There was a trend (p = 0.06) towards
decline in responses to SNP during acute phases of CAS.