2.4 | Homology modelling of the Kv1.5 channel
The Kv1.5 model previously reported by our group was used to study the binding site for local anesthetics (Marzian, Stansfeld et al. , 2013). Briefly, the crystal structure of the open state Kv1.2-Kv2.1 chimera (PDB code: 2R9R) (Long, Tao et al. , 2007) was used as template. The modelled transmembrane region of Kv1.5 includes the residues 269-526, which correspond to residues 160-417 of the template. Modeller 9v5 (Sali & Blundell, 1993) was used to create Kv1.5 homology model.