Aytug K. Kiper1,§, Sarah Stalke1,§, Stefanie Marzian1,§, Mauricio Bedoya2,3,§, David Ramírez4, Alicia de la Cruz5,6, Diego A. Peraza5,6, José C.E. Márquez Montesinos2, Bárbara A. Arévalo Ramos2, Susanne Rinné1, Teresa Gonzalez5,6,7, Carmen Valenzuela5,6,*, Wendy Gonzalez2,3,* and Niels Decher1,*
1Institute for Physiology and Pathophysiology, University of Marburg, Marburg, Germany.
2Centro de Bioinformática y Simulación Molecular, Universidad de Talca, Talca, Chile.
3Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Universidad de Talca, Talca, Chile.
4Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.
5Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Madrid, Spain.
6Spanish Network for Biomedical Research in Cardiovascular Research (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain.
7Biochemistry Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
§Kiper AK, Stalke S, Marzian S and Bedoya M are joint first author.
*Valenzuela C, Gonzalez W and Decher N are corresponding authors.
Running title: Essential binding site for local anesthetics in the Kv ‘side pockets´
Prof. Dr. Niels Decher
Institute for Physiology and Pathophysiology
Philipps-University Marburg
Deutschhausstraße 2
35037 Marburg, Germany
T: + 49-6421-28-62148
decher@staff.uni-marburg.de
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