When it comes to preterm birth, innovative ways are needed without doubt, as EOGBS sepsis in this group of infants results in a much higher case-fatality rate compared to term infants.3 Besides, little data is available on the role of GBS infection as the cause of preterm birth. Most screening-protocols suggest all women with impeding preterm birth receive IAP. More targeted prophylaxis might reduce overtreatment and potentially reduce the occurrence of late-onset sepsis as early antibiotic exposure is a risk-factor for NEC and late-onset sepsis. Once timely PCR-testing is fully validated and implemented, important steps could be made to understand and to protect this group.