AUTHOR CONTRIBUTIONS
E.R., P.H., and M.M. have prospectively collected HPE clinical DNA samples and data. M.T., and S.H. prepared the synthetic mRNA andin situ probes. M.T. collected embryos, performed in vivoexperiments and biological analysis. B.C. and R.S., from the NHGRI Zebrafish Core, designed the CRISPR/cas9 K/O model. B.C. performed experiments to create the CRISPR/cas9 K/O model. M.T., and B.C., performed genotyping. E.R., S.H., and M.T., contributed to the design of the study and data interpretation. M.T. prepared the figures. M.T., E.R., S.H., P.H. and B.C. wrote the manuscript. All authors reviewed and approved the final draft of the manuscript.