Figure legends:
Figure-1 : Work flow the study and details of Genotyping, data processing and quality controls and screen shot ClinIndb databse.
Figure 2: Diversity and relatedness of Indian populations with respect to 1000 genomes SAS and EAS super populations. Majority of the IE and DR large populations are covered by SAS group. EAS group is distinct from TB populations of India. Isolated AA and DR populations not covered by any of the 1000 genomes populations. Keys outside the main figure represent different populations: Circles - IGV populations, plus sign - SAS and EAS super populations from 1000 genomes.
Figure 3: Sufficient coverage of IE and DR large populations as well as TB cluster (by highlanders) by our cohorts in this study with the exception of isolated groups. Keys outside the main figure represent different populations: Filled circles - Cohorts in this study, Unfilled circles - IGV populations, plus sign -1000 genomes SAS and EAS super populations.
Figure-4: Spectrum of Pathogenic Variants in Clindb and other genomic databases (SAS Populations) A) Number of variants containing either “pathogenic” or “likely pathogenic” term were compared across different SAS populations in global databases. gnomAD_SAS is representative of both gnomAD and ExAc SAS groups. B) Absolute average frequency differences of Clindb and GAsP (SAS) were compared with 1000G, ExAc and gnoMAD SAS groups