ZCMEI-21 questionnaire
The ZCMEI-21 recently was developed and validated as a disease-specific questionnaire for chronic middle ear disease.6 It has successfully been applied in first clinical trials.10,17–19 The ZCMEI-21 consists of four subscales investigating ear specific symptoms, hearing, psychosocial impact and the use of medical resources. Answers are presented using a five-point Likert scale. High scores correlate with a poorer quality of life and the minimal clinically important difference (MCID) of the ZCMEI-21 is estimated at 5 points.19