Synopsis of key findings
This study reports differing symptoms and different HRQoL depending on
the type of CMED. Although an overall clinically relevant improvement in
HRQoL19 was found after surgical therapy, subgroup
analysis only revealed significant improvement in COM with epitympanic
cholesteatoma, COM without cholesteatoma and persistent mastoid cavity
without recurrent cholesteatoma. No significant improvements were found
in COM with pars tensa cholesteatoma, persistent mastoid cavity with
recurrent cholesteatoma, and revision ossiculoplasty for hearing
restoration. Postoperatively, however, no differences in HRQoL were
found.