ZCMEI-21 questionnaire
The ZCMEI-21 recently was developed and validated as a disease-specific
questionnaire for chronic middle ear disease.6 It has
successfully been applied in first clinical
trials.10,17–19 The ZCMEI-21 consists of four
subscales investigating ear specific symptoms, hearing, psychosocial
impact and the use of medical resources. Answers are presented using a
five-point Likert scale. High scores correlate with a poorer quality of
life and the minimal clinically important difference (MCID) of the
ZCMEI-21 is estimated at 5 points.19