aNumber of descriptor values fall outside values of 95
% known drugs (recommended range: 0 to 5)
bNumber of rotatable bonds (recommended range: 0-15)
c Total solvent accessible surface area (SASA) in
square angstroms (recommended range: 300 to 1000)
dNumber of hydrogen-bond donors (recommended range: 0
to 6)
e Number of hydrogen-bond acceptors (recommended
range: 2 to 20)
f Predicted octanol/water partition coefficient
(recommended range: –2 to 6.5)
gPredicted skin permeability (recommended range: –8.0
to –1.0)