Discussion
It’s largely known that endometriosis has challenging impact on infertility treatment. Both, couples and doctors are starting the infertility treatment with high hopes but as our results, 20% of couples with endometriosis related infertility (ERI) are knocked down in this battle because of cycle cancellation.
In this study we aimed to elucidate whether the phenotype of endometriosis affects the number of cancelled cycles, and to obtain the factors related with cancelled cycles. Our findings clearly indicated that phenotype of endometriosis does not affect the success of cycles and only ovarian reserve markers, particularly AFC, have prognostic value to predict the risk of cancelling the cycle.
The cycle cancellation rate (CCR) of all ERI cycles was 19.8% in our study. There are limited numbers of studies, which inform about cycle cancellation rates of ERI. All of these studies have different CC rates. CC rates of studies in the literature are variable between 7.5% and 47.1%.(8,9,14) Our CC results are 16.6% in SUP, 19.7% in OMA and 21.2% in DE group.
According to our results, we found four prognostic factors related with CC. These factors are age, ovarian reserve (day3 FSH, AMH and AFC), adenomyosis rate and laparotomy rate. With logistic regression analysis, antral follicle count is the only independent factor related with cycle cancellation.