PCOS AND UTERİNE ABNORMALITY; POSSIBLE CONNECTION AND RELATIONSHIP WITH
MATERNAL SERUM AMH LEVELS
Abstract
Objective: To determine the incidence of uterine abnormalities in
patients with PCOS Design: Retrospective Cohort Study Setting: Tertiary
University Hospital Population: Infertile patients with PCOS vs. male
factor infertility were selected from the IVF center electronic database
from between the years 2011-2019. Methods: A total of 103 patients, 51
PCOS, and 52 male factor infertility were enrolled in the study.
Hysterosalpingography (HSG) images of all patients were numbered. For
the study, six different shapes of the intrauterine cavity were figured.
All HSG images were evaluated by ten senior reproductive
endocrinologists and surgeons. Seniors were blinded to the research and
chose the most appropriate figure for each patient’s HSG image. Results
and Demographic parameters were compared between PCOS and Male Factor
Groups. Anti-Mullerian hormone correlation with Uterine abnormality was
further analyzed. Main Outcome Measure: Percentage of the abnormal
uterine cavity Results: The percentage of the normal uterine cavity was
significantly lower in the PCOS group. (45.9 % and 73.1 %,
p<0.01) The abnormal cavities were compared; Arcuate Uterus
(22.18% vs 6.6% p<0.05), Partial Septate Uterus (5.1% vs
0% p<0.05), Complete Septate Uterus (5.47% vs 1.2%
p<0.01) and Y-Shaped Uterus (7.47% vs 0 p<0.05)
were significantly higher in PCOS patients. T-Shaped Uterus (13.8% vs.
18.9%) was statically similar. There was no correlation between serum
AMH levels and the presence of uterine abnormality. Conclusion: This
study provides that, compared to the healthy population, the uterine
abnormality frequency is clearly higher Key Words: Polycystic Ovary
Syndrome, Uterine Abnormality, Anti-Mullerian Hormone