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PCOS AND UTERİNE ABNORMALITY; POSSIBLE CONNECTION AND RELATIONSHIP WITH MATERNAL SERUM AMH LEVELS
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  • Gurkan Uncu,
  • Kiper Aslan,
  • Ozge Albayrak,
  • Aylin Orhaner,
  • Isil Kasapoglu
Gurkan Uncu
Uludag University School of Medicine
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Kiper Aslan
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Ozge Albayrak
Uludag University Faculty of Medicine
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Aylin Orhaner
Uludag University School of Medicine
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Isil Kasapoglu
Uludag University Faculty of Medicine
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Abstract

Objective: To determine the incidence of uterine abnormalities in patients with PCOS Design: Retrospective Cohort Study Setting: Tertiary University Hospital Population: Infertile patients with PCOS vs. male factor infertility were selected from the IVF center electronic database from between the years 2011-2019. Methods: A total of 103 patients, 51 PCOS, and 52 male factor infertility were enrolled in the study. Hysterosalpingography (HSG) images of all patients were numbered. For the study, six different shapes of the intrauterine cavity were figured. All HSG images were evaluated by ten senior reproductive endocrinologists and surgeons. Seniors were blinded to the research and chose the most appropriate figure for each patient’s HSG image. Results and Demographic parameters were compared between PCOS and Male Factor Groups. Anti-Mullerian hormone correlation with Uterine abnormality was further analyzed. Main Outcome Measure: Percentage of the abnormal uterine cavity Results: The percentage of the normal uterine cavity was significantly lower in the PCOS group. (45.9 % and 73.1 %, p<0.01) The abnormal cavities were compared; Arcuate Uterus (22.18% vs 6.6% p<0.05), Partial Septate Uterus (5.1% vs 0% p<0.05), Complete Septate Uterus (5.47% vs 1.2% p<0.01) and Y-Shaped Uterus (7.47% vs 0 p<0.05) were significantly higher in PCOS patients. T-Shaped Uterus (13.8% vs. 18.9%) was statically similar. There was no correlation between serum AMH levels and the presence of uterine abnormality. Conclusion: This study provides that, compared to the healthy population, the uterine abnormality frequency is clearly higher Key Words: Polycystic Ovary Syndrome, Uterine Abnormality, Anti-Mullerian Hormone