Conclusion:
We found that the frequency of uterine abnormality is more common in PCOS patients than the normal population and this is not correlated with maternal serum AMH levels.
Considering that PCOS is a transgenerational and transmissible disease, high frequency of uterine cavity abnormalities in PCOS patients can be attributed to increased, either direct effect of cord blood AMH levels to uterine development via WNT genes or indirect effect of AMH via increasing intrauterine GnRh Pulsatility - LH levels or reducing placental aromatase enzyme which is blocking maternal androgens, intrauterine androgens and downregulation of HOXA genes. (Figure 4)
Longitudinal studies are needed to investigate the relationship between umbilical cord AMH, androgens and other sex steroids levels, shape of uterine cavity and pregnancy complications.