Pathogenicity of the isolated S. pseudintermedius in
mice
To assess the pathogenicity of the isolated S. pseudintermedius,6 mice were artificially inoculated using the purified bacterial. After
14 days post inoculation (dpi), the symptoms such as lethargy,
depression, loss of appetite, closing eyes, fear of cold, drowsiness,
crouching in cages, fur wrinkles occurred in all the six mice; in five
of six mice, the obvious ulceration and suppuration appeared in the
abdominal skins or hind limb (Fig. 7); but none of six mice was dead in
two weeks. After anatomy, swelling and bleeding in varying degrees
occurred in the lungs, hearts, livers, kidneys; even hemorrhage and
necrosis did in some mice (Fig. 8), which were consistent with those of
the diseased raccoon dogs. Correspondingly, the pathogen was isolated
from the ulcerative skin and lungs of the infected mice, and was
identified as S. pseudintermedius . It was confirmed that the
isolated S.pseudointermediate from the diseased raccoon dogs can
cause sever lesions in mice.