Definition
Progressive TR was defined as increased TR grade of ≥2 degrees and/or
TRPG of >30 mmHg after implant, and TRPG of
>30 mmHg was suggestive of possible pulmonary hypertension9. Moderate TR (grade III) was defined as a
regurgitant jet extending to less than half of the right atrium, whereas
severe TR (grade IV) as a jet extending to more than half of the length
of the right atrium 10. HF hospitalization was defined
as the occurrence of HF events according to a New York Heart Association
functional class of III or IV in the absence of other alternative
diagnoses. HF symptoms were
classified as the New York Heart Association functional class II-IV
required medical treatment. Cardiovascular mortality was defined as
sudden death related to arrhythmias, HF, and myocardial infarction.
All-cause mortality was defined as death related to any cause, such as
sudden death with undefined reasons, natural course, sepsis, malignancy,
and cardiovascular disease.