Definition
Progressive TR was defined as increased TR grade of ≥2 degrees and/or TRPG of >30 mmHg after implant, and TRPG of >30 mmHg was suggestive of possible pulmonary hypertension9. Moderate TR (grade III) was defined as a regurgitant jet extending to less than half of the right atrium, whereas severe TR (grade IV) as a jet extending to more than half of the length of the right atrium 10. HF hospitalization was defined as the occurrence of HF events according to a New York Heart Association functional class of III or IV in the absence of other alternative diagnoses. HF symptoms were classified as the New York Heart Association functional class II-IV required medical treatment. Cardiovascular mortality was defined as sudden death related to arrhythmias, HF, and myocardial infarction. All-cause mortality was defined as death related to any cause, such as sudden death with undefined reasons, natural course, sepsis, malignancy, and cardiovascular disease.