INTRODUCTION
Drug
reaction with eosinophilia and systemic symptoms (DRESS syndrome) is a
quite unusual condition related to drug reaction.1Several drugs have been linked to DRESS. It is a severe idiosyncratic
drug reaction characterised by erythematous or papulo–pustular skin
eruption associated with lymphadenopathy, fever, and visceral
involvement (hepatitis, nephritis pneumonitis, pericarditis,
myocarditis, and colitis).2-6 Leucocytosis,
eosinophilia (90%) and/or mononucleosis (40%) also may be
seen.6 Severe acute hepatitis due to sulfasalazine or
Trimethoprim-sulfamethoxazole is described in literature, but the
occurrence of DRESS and liver failure is rare.
In this study, we report a patient with acute liver failure due to
sulfasalazineÂ-induced DRESS, treated with liver transplant.