INTRODUCTION
Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) is a quite unusual condition related to drug reaction.1Several drugs have been linked to DRESS. It is a severe idiosyncratic drug reaction characterised by erythematous or papulo–pustular skin eruption associated with lymphadenopathy, fever, and visceral involvement (hepatitis, nephritis pneumonitis, pericarditis, myocarditis, and colitis).2-6 Leucocytosis, eosinophilia (90%) and/or mononucleosis (40%) also may be seen.6 Severe acute hepatitis due to sulfasalazine or Trimethoprim-sulfamethoxazole is described in literature, but the occurrence of DRESS and liver failure is rare.
In this study, we report a patient with acute liver failure due to sulfasalazine­-induced DRESS, treated with liver transplant.