Data and analysis
Data were expressed as mean ± standard deviation (SD). Numbers for every experiment (and group) are given in the figure legends and refer to the number of every individual animals used in the respective group. Data obtained from inappropriate measurements (e.g. mouse dying during blood sampling) were excluded. Data were analyzed by one-way analysis of variance followed by Tukey’s test using the SPSS 17.0 (IBM, USA). Note that p-values less than 0.05 was considered to be statistically significant (i.e.,*p <0.05, **p< 0.01, or ***p <0.001). All data were analyzed without any transformation except the data from ED50 measurements, which were log-transformed.