In vivo methods
Experimental models of toxicity were developed in spontaneously breathing rats, ventilated rats and ventilated rabbits, in which chloroquine was infused at different rates, and measurements taken of haemodynamic and electrocardiographic parameters. Interventional studies were then conducted in which chloroquine-intoxicated rats were treated with combinations of diazepam, clonazepam, Ro5-4864, adrenaline or vehicle control.