In vivo methods
Experimental models of toxicity were developed in spontaneously
breathing rats, ventilated rats and ventilated rabbits, in which
chloroquine was infused at different rates, and measurements taken of
haemodynamic and electrocardiographic parameters. Interventional studies
were then conducted in which chloroquine-intoxicated rats were treated
with combinations of diazepam, clonazepam, Ro5-4864, adrenaline or
vehicle control.