(v) Efficacy of diazepam (during infusion of chloroquine) with a
non-barbiturate anaesthetic
Over 30 minutes of administration, chloroquine only significantly
affected the PR and QRS intervals. There were no subsequent differences
between groups, following administration of diazepam or vehicle control,
in any of the measured parameters (Table 3). A further randomised trial
was initiated with chloroquine infused at a higher rate of 2 mg
kg-1 min-1 in order to evaluate the
effects of diazepam with more pronounced toxicity, however, 5 of the
first 9 rats recruited died, and the study was terminated.