Correlation of HPV with inverted papilloma with malignant transformation.
From this study, three out of 44 patients had IP with synchronous SCC. They were classified into the group IP with SCC (Table 1). During this study period, no patients had metachronous SCC. Two out of these three patients had positive HPV results. Both HPV 16 and 18 were detected in the two patients.
Our results showed an association between HPV 16 and 18 infection with malignant transformation (p<0.05). The HPV 16 infection and malignant transformation was statistically significant with a p value of 0.013 while HPV 18 infection and malignant transformation showed a p value of 0.003 (Table 1).