Population of the study
We included 964 patients with stable CAD. Two patients were lost to follow-up, leaving 962 patients for the analysis, who were followed for an average period of 5.40 (2.81-6.94) years.
Of the 962 patients studied, 59 developed cancer during follow-up. We divided the sample in three subgroups: patients who did not develop cancer during follow-up (group A; N=903), those receiving a cancer diagnosis in the first 3 years of follow-up (group B; N=30), and patients receiving a cancer diagnosis beyond 3 years (group C; N=29). Table 1 shows the baseline characteristics of the patients.
In the group B there were 15 (50.0%) carcinomas, 11 (36.7%) adenocarcinomas, 3 (10.0%) cancers with other histology, and 1 (3.3%) case of unknown etiology. In group C these values were 13 (44.8%), 11 (37.9%), 5 (17.2%), and 0 (0.0%), respectively. The case of unknown histology corresponded to a 83-year-old man with images clearly compatible with lung cancer with metastases, who was dying and the doctors decided not to perform histological analysis. Table 2 shows the locations of the cancers.