Conclusion:

Truncus arteriosus is infrequent congenital heart disease with mortality comparable to that following Norwood procedure. Mortality rates have trended down over time although continue to remain high. 22q11.2 deletion was not associated with increased mortality compared to subjects without this deletion. However, this subject population had a higher incidence of non-cardiac anomalies, higher need for tracheostomy and G-tube placement, protracted length of stay with an increased cost of hospitalization. Prematurity, non-White race, and use of Medicaid insurance were factors associated with higher mortality. These findings will help direct prenatal counseling and management postnatally.