Future directions
An updated review of described cases is necessary to add to the body of evidence and improve the quality of data. In addition, further studies on the pathophysiology and possible markers are needed to better understand this disease.
There is also need for better reporting of available data, described cases should be thorough and include exams, interventions and both fetal and maternal outcomes. We highly recommend that in the suspicion of mirror syndrome, attending physicians request PlGF and sFlt-1 exams to help validate these tools as a diagnostic aid since currently there isn’t enough evidence to qualify these markers and the diagnosis of Mirror syndrome remains a challenge.