Conclusion
Knowledge on the effects of statin treatment initiating on
anticoagulation in stable VKA treatment is limited. Despite different
types of VKA and statins, a tendency of an increased anticoagulant
effect following statin treatment, when initiated while in VKA treatment
was observed in the included studies. Considering initiation of
simvastatin treatment in patients treated with warfarin, the reported
increase in anticoagulation is limited and overall considered to be
without clinical relevance. The anticoagulant effect of initiation of
other statins vary, and it should be evaluated individually, if the
frequency of INR monitoring should be increased during the first period
of concomitant treatment.