Appendix X
The databases PubMed and Embase were searched from inception until February 13, 2020. Eligible studies included human subjects, presented data on vitamin K antagonist use and new statin use, and reported outcomes of changes in INR or proxies herefore. We imposed no restrictions regarding language or publication date on the search. Abstracts, conference proceedings, and unpublished work were not included. Besides original studies, reviews were eligible for full-text screening to identify additional references. Titles and abstracts were screened by two medical doctors (AEE and ALS) independently. Disagreements were resolved by consensus. We searched references in all publications selected for full-text screening to detect relevant potential publications not identified by our search strategy. Furthermore, the interaction databases of the Danish Medicines Agency (www.interaktionsdatabasen.dk), Stockleys Interaction Checker, and Lexicomp/Uptodate.com were reviewed for additional references.
Example of the full search strategy in EMBASE
1. exp hydroxymethylglutaryl coenzyme A reductase inhibitor/
2. (statin or statins).mp.
3. atorvastatin.mp.
4. cerivastatin.mp.
5. fluvastatin.mp.
6. lovastatin.mp.
7. pravastatin.mp.
8. simvastatin.mp.
9. lipitor.mp.
10. baycol.mp.
11. lescol.mp.
12. mevacor.mp.
13. altocor.mp.
14. pravachol.mp.
15. lipostat.mp.
16. zocor.mp.
17. mevinolin.mp.
18. compactin.mp.
19. fluindostatin.mp.
20. rosuvastatin.mp.
21. hydroxymethylglutaryl*.mp.
22. HMG-CoA*.mp.
23. 1 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22
24. exp coumarin anticoagulant/
25. exp antivitamin K/
26. coumarin derivative/ or 4 hydroxycoumarin/ or 4 hydroxycoumarin derivative/
27. (Vitamin K antagonist$ or VKA or VKAs).mp.
28. (4-hydroxycoumarin* or warfarin* or acenocoumarol or nicoumalone or sinthrome or sintrom or phenindione or dicoumarol or coumadin or phenprocoumon or phepromaron or ethyl-biscoumacetate or phenindione or Diphenadione or Tioclomarol or Racumi or Marcoumar or Marcumar or Falithrom or Jantoven or fluindione or difenacoum or coumatetralyl).mp.
29. (coumarin$ or cumarin$ or phenprocoum$ or phenprocum$ or dicoumar$ or dicumar$ or acenocoumar$ or acenocumar$ or coumadin$ or fluindione dionor phenindione or clorindione or diphenadione).mp.
30. (adoisine or aldocumar or athrombin$ k or carfin or coumafene or coumaphene or jantoven or kumatox or lawarin or marevan or panwarfarin or panwarfin or prothromadin or sofarin or tedicumar or tintorane or waran or warfant or warfilone or warnerin).mp.
31. international normalized ratio/
32. international normalised ratio.mp.
33. international normalized ratio.mp.
34. 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33
35. 23 and 34
36. limit 35 to (animals and animal studies)
37. 35 not 36
38. limit 37 to conference abstract
39. 37 not 38